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For those with normal absorption and adequate B12 stores, injections provide no unique metabolic advantage

1h) and dose-responsive degradation was assessed by HiBiT, determining half-maximal degradation concentration (DC 50 ) values ranging from 50 nM to 1.85 M and maximal degradation ( D max ) ranging from 91% to 58% (Extended Data Fig

Histopathological analysis involved fixing left lung lobes in 10% neutral formalin, embedding in paraffin, sectioning into 4 m thick sections, and staining with hematoxylin and eosin (H&E)

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Deficiency causes megaloblastic anemia abnormally large, poorly functioning red blood cells which reduces the blood's oxygen-carrying capacity and contributes to fatigue, pallor, and shortness of breath